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University of Miami initiates clinical trial of XM-ONEŽ - Press release

Thursday, 07 June 2012
The transplantation unit at Jackson Memorial Hospital and the University of Miami, FL, USA has entered into a research project with the Allenex group company AbSorber. The project is a pilot study evaluating the endothelial cell cross matches XM-ONEŽ in their Living Donor program. University of Miami will investigate if antibodies detected by XM-ONEŽ will affect the outcome for the individual patient, in pre- and post-transplant situations.

“Non-HLA antibodies, especially endothelial cell antibodies, play a significant role as risk markers of acute rejection in kidney transplant recipients” says Dr. Giselle Guerro, MD at the University of Miami and principal investigator of the study. “However, the post-transplant risk evaluation of these antibodies have not been studied and we are excited to have this possibility”, she continues.

This prospective pilot study will include 138 patients and is estimated to have an enrollment period of two years. Patients will thereafter be monitored for six months post transplantation.
“The last years a number of researchers have published important data on the relevance of non-HLA antibodies as well as XM-ONEŽ used for risk assessment in a pre-transplant setting. An obvious next step is to investigate the presence and importance of non-HLA antibodies post-transplantation using XM-ONEŽ. We are proud that Dr. Guerro and her co-workers at Jackson Memorial Hospital approached us to perform this important study”, says Anders Karlsson, CEO of Allenex.
Based on press release

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